Hiroaki Shimokawa Selected Research

Serotonin (5 Hydroxytryptamine)

2/2017	Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries.
2/2016	Beneficial Effects of a Novel Bioabsorbable Polymer Coating on Enhanced Coronary Vasoconstricting Responses After Drug-Eluting Stent Implantation in Pigs in Vivo.
9/2006	Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo: a possible link between stress and coronary vasospasm.
5/2004	Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
2/2002	Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Hiroaki Shimokawa Research Topics

Disease

71	Heart Failure 03/2024 - 03/2002
49	Cardiovascular Diseases (Cardiovascular Disease) 03/2023 - 03/2002
45	Myocardial Infarction 12/2022 - 05/2004
41	Pulmonary Hypertension 01/2021 - 07/2002
40	Myocardial Ischemia (Ischemic Heart Diseases) 12/2023 - 01/2002
31	Coronary Artery Disease (Coronary Atherosclerosis) 08/2023 - 01/2002
31	Inflammation (Inflammations) 01/2023 - 02/2002
28	Spasm (Spasms) 02/2022 - 02/2002
28	Hypertension (High Blood Pressure) 01/2022 - 04/2002
26	Stroke (Strokes) 12/2022 - 02/2002
24	Hypoxia (Hypoxemia) 01/2021 - 07/2002
23	Coronary Vasospasm (Coronary Artery Vasospasm) 01/2023 - 03/2002
21	Ischemia 09/2021 - 07/2003
21	Pulmonary Arterial Hypertension 01/2021 - 01/2005
20	Fibrosis (Cirrhosis) 01/2021 - 02/2002
19	Shock 01/2022 - 11/2004
17	Arteriosclerosis 01/2016 - 02/2002
15	Thrombosis (Thrombus) 01/2022 - 04/2002
15	Atherosclerosis 10/2018 - 03/2002
14	Atrial Fibrillation 11/2023 - 12/2016
11	Reperfusion Injury 01/2016 - 08/2004
10	Neoplasms (Cancer) 12/2023 - 11/2010
10	Hemorrhage 06/2023 - 02/2008
10	Hypertrophy 01/2021 - 10/2003
10	Cardiomyopathies (Cardiomyopathy) 01/2021 - 05/2002
9	Unstable Angina 11/2023 - 01/2016
9	Angina Pectoris 01/2023 - 01/2005
9	Chest Pain (Chest Pains) 01/2023 - 03/2002
8	Pathologic Constriction (Stenosis) 01/2022 - 04/2002
8	Ventricular Tachycardia 12/2021 - 01/2015
8	Diabetes Mellitus 01/2020 - 10/2004
7	Cognitive Dysfunction 05/2024 - 01/2017
7	Ventricular Remodeling 01/2018 - 05/2004
7	Vascular Remodeling 01/2018 - 12/2002
7	Vascular Diseases (Vascular Disease) 11/2010 - 02/2002
6	Death (Near-Death Experience) 01/2022 - 09/2010
6	Cardiac Sudden Death (Sudden Cardiac Arrest) 12/2021 - 05/2004
6	Cardiomegaly (Heart Hypertrophy) 05/2016 - 01/2005
5	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 09/2018
5	Stable Angina 01/2023 - 01/2005
5	Tachycardia (Tachyarrhythmias) 01/2023 - 05/2007
5	Acute Coronary Syndrome 11/2021 - 04/2002
5	Ischemic Stroke 09/2021 - 12/2016
5	Embolism (Embolus) 09/2021 - 12/2016
5	Atherosclerotic Plaque (Atheroma) 12/2020 - 04/2002
5	Infarction (Infarctions) 01/2018 - 07/2004
5	Right Ventricular Hypertrophy 06/2014 - 02/2004
4	Microvascular Angina (Cardiac Syndrome X) 12/2022 - 01/2003
4	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 10/2022 - 09/2018
4	Ventricular Fibrillation 12/2021 - 04/2009
4	Coronary Stenosis (Coronary Artery Stenosis) 01/2021 - 03/2003

Drug/Important Bio-Agent (IBA)

80	rho-Associated KinasesIBA 01/2023 - 02/2002
29	fasudil (AT 877)IBA 12/2019 - 04/2002
25	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2023 - 02/2002
19	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 03/2024 - 07/2003
17	Proteins (Proteins, Gene)FDA Link 03/2024 - 07/2002
17	Vasodilator Agents (Vasodilators)IBA 01/2023 - 07/2003
17	Acetylcholine (Acetylcholine Chloride)FDA Link 02/2022 - 03/2002
14	Brain Natriuretic Peptide (Natrecor)FDA Link 03/2024 - 09/2008
14	Biomarkers (Surrogate Marker)IBA 01/2023 - 05/2008
13	Nitric Oxide Synthase (NO Synthase)IBA 11/2023 - 02/2004
13	omega-Chloroacetophenone (Mace)IBA 01/2023 - 09/2010
12	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2024 - 02/2002
10	CytokinesIBA 03/2024 - 05/2002
10	Protein Isoforms (Isoforms)IBA 11/2023 - 07/2005
10	LipidsIBA 08/2023 - 09/2010
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2019 - 07/2003
10	hydroxyfasudilIBA 02/2016 - 02/2002
10	Angiotensin IIIBA 05/2015 - 02/2002
10	Monomeric GTP-Binding ProteinsIBA 01/2015 - 02/2002
9	MonocrotalineIBA 01/2021 - 02/2004
9	NitratesIBA 08/2020 - 10/2004
9	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2020 - 02/2003
8	Cyclophilin AIBA 01/2021 - 11/2010
7	RivaroxabanIBA 11/2023 - 12/2016
7	pitavastatin (itavastatin)FDA Link 08/2023 - 01/2018
7	LDL CholesterolIBA 08/2023 - 09/2010
7	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2023 - 10/2004
7	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 03/2002
6	Messenger RNA (mRNA)IBA 11/2023 - 07/2002
6	CreatinineIBA 01/2021 - 09/2004
6	Erythropoietin FDA Link 10/2011 - 03/2006
5	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/2024 - 03/2009
5	pro-brain natriuretic peptide (1-76)IBA 03/2024 - 01/2019
5	AnticoagulantsIBA 12/2023 - 11/2008
5	Angiotensin Receptor AntagonistsIBA 01/2022 - 07/2013
5	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 08/2020 - 09/2006
5	Serotonin (5 Hydroxytryptamine)IBA 02/2017 - 02/2002
5	endothelium-dependent hyperpolarization factor (EDHF)IBA 01/2015 - 05/2005
4	LDL Receptors (LDL Receptor)IBA 01/2021 - 09/2010

Therapy/Procedure

78	Therapeutics 05/2024 - 09/2002
20	Extracorporeal Shockwave Therapy 07/2023 - 11/2004
16	Percutaneous Coronary Intervention 06/2023 - 01/2005
10	Stents 03/2020 - 04/2002
9	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 02/2022 - 04/2009
6	Catheter Ablation 06/2021 - 01/2015
6	Ligation 01/2019 - 12/2002
5	Drug-Eluting Stents 01/2021 - 01/2012
5	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2011 - 09/2004
4	Secondary Prevention 02/2022 - 02/2012